Adults need approximately 1 microgram/kg body weight of vitamin K a day. Be active in ways you enjoy. Get useful, helpful and relevant health + wellness information. The prothrombin gene mutation can make you more likely to get harmful blood clots, but you may never get one. Here's some information to help you prepare for your appointment. Factor V Leiden thrombophilia. Most people with factor V Leiden never develop abnormal clots. Often, those treatments will require hospitalization. As a result, clotting goes on longer than usual. Clotting Disorders. Following your providers guidance can help you catch and resolve problems early before they interrupt the flow of your life. 2. AskMayoExpert. Diets ideal for this include the Mediterranean diet and the DASH diet. Blood clots in less commonly affected veins, like those in your liver or brain. Lockwood CJ, et al. 2005 - 2023 WebMD LLC. A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. Still, there is research that suggests that a diet of low GI foods is more likely to cause weight loss, at least in the short term. 0000007946 00000 n Wear compression stockings if your provider prescribes them for you. Its the most common blood clotting disorder thats inherited, or passed down within biological families. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. Check with your provider. 0 professional diagnosis, opinion, treatment, or services to you or any individual. These proteins are essential helpers that support hemostasis. 0000002967 00000 n https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Stand up and walk around during long flights. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. These include: Talk to your healthcare provider about your risk of developing blood clots and what precautions you should take. PO Box 825687 If you are homozygous, you will pass the mutation on to your children. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Factor V Leiden This results from a genetic change that increases the risk of blood clots, especially in deep veins. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/#resources). In addition, this mutation only increases the risk of vein clots (deep vein thrombosis or pulmonary embolism). 2. Keeping your intake of vitamin K at a even level will help maintain your blood thinners (especially warfarin) levels. Some people only need treatment for three months, but others will need blood thinner treatment indefinitely. What information will come out of the test? This content does not have an Arabic version. Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. Its important to learn the symptoms so you can seek immediate medical care. You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent. Most people with this disorder never develop a blood clot. Because its an inherited condition, you cant prevent the prothrombin gene mutation. But the plan would have to be modified to make it appropriate if you have these or other conditions. Hormones and birth control pills also increase womens risk of blood clots. The risk increases with age: Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Talk to your provider to see if you should be taking a blood thinner. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. People with factor V Leiden have a mutation in their coagulation factor V (F5) gene. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. Factor V Leiden (pronounced FAK-ter five LYE-den) is a blood clotting disorder that raises your risk of abnormal blood clots. This site complies with the HONcode standard for trustworthy health information: verify here. endstream endobj 77 0 obj<> endobj 79 0 obj<>/Font<>>>/DA(/Helv 0 Tf 0 g )>> endobj 80 0 obj<> endobj 81 0 obj<>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>> endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj[/ICCBased 102 0 R] endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<>stream Some research shows that factor V Leiden impacts pregnancy. Enjoy a variety of foods from the 4 food groups. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). If you have never had a blood clot, you do not need treatment with blood thinners. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. This change causes it to resist other proteins that stop excessive clotting. But you will have to be very organized and motivated to stay on track. U.S. National Institutes of Health, National Library of Medicine. with these terms and conditions. 1-ranked heart program in the United States. People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Talk to your healthcare provider to receive advice tailored to your needs. 0000006951 00000 n You probably wont know you have prothrombin gene mutation unless you have a specific blood test if/after you develop a deep vein thrombosis or pulmonary embolism. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Late in my pregnancy I started having horrible swelling in my legs. .wpcdt-timer-24806 {background-color: #aaaaaa;}.wpcdt-timer-24806 .wpcdt-title, .wpcdt-timer-24806 .wpcdt-desc, .wpcdt-timer-24806 .wpcdt-desc p{color: #b81d32;}.wpcdt-timer-24806 .wpcdt-clock-circle h4, A. Your provider may think you have a clotting problem if you: There is no specific treatment for the mutation itself. 0000001564 00000 n If you have the homozygous type, your child will inherit a Factor V Leiden gene. We inherit one gene from our mother and one from our father. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. The factor V Leiden mutation itself doesnt have any specific treatment. Check with your doctor or dietitian first. Women have a greater chance of developing a blood clot during pregnancy. Please note that medical information found Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. 2019. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Factor V Leiden is also known under its other name Factor V Leiden Thrombophilia. Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. If you have factor V Leiden, you may have many questions. DVT or a PE soon after starting birth control pills or hormone therapy. It is recommended that patients on anticoagulants drink two or fewer alcoholic drinks per day. In fact, the vast majority (9 out of 10) never develop abnormal blood clots. It increases the chances that your blood will form abnormal blood clots that can be dangerous. News-Medical. 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If you have Factor V Leiden, you have a greater chance of developing blood clots. Complex carbohydrates (vegetables, sweet potato, wild rice, beans, lentils, oatmeal, quinoa). Barbara Woodward Lips Patient Education Center. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. We do not endorse non-Cleveland Clinic products or services. 1-ranked heart program in the United States. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. NBCA provides the information and materials on this site for general information purposes only. The Top 5 Worst Foods for Your Heart, According to a Dietitian. If youre taking anticoagulants (blood thinners), be aware that you may bleed or bruise more easily, which is why it is very important to have regular follow-up medical appointments with your provider. What are my risks? You should not rely on the information provided as a substitute for actual professional medical This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. The two most common hereditary thrombophilia conditions are the factor V Leiden and prothrombin 20210 gene mutations, both of which have been the subject of previous Cardiology Patient Pages. Barbara Woodward Lips Patient Education Center. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, It is generally advised that patients taking anticoagulants keep to a balanced and consistent diet balanced throughout their treatment course to avoid fluctuations in treatment efficacy. How long will it take to get results back? Deep vein thrombosis and pulmonary embolism. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. A single copy of these materials may be reprinted for noncommercial personal use only. Where's the Health Benefit? But if you do develop clots, be assured there are treatments that can help. If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Going on a long flight or a very long road trip. Why? The liver is responsible for breaking down alcohol and some medications, and this may cause a slower than normal metabolism of the anticoagulant, increasing the drug concentration in the blood, and hence the risk of bleeding. Your skin may also feel warm to the touch or look red or discolored. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. In rare cases, you may need a catheter procedure or surgery to remove the bulk of the clots. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. U.S. National Institutes of Health, National Human Genome Research Institute. Follow Canadas Physical Activity Guide. Ask your provider for resources to, Limit alcohol intake, and avoid it during long flights (it can lead to, Move around more. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, Thomas SH, eds. All rights reserved. Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. 0000237061 00000 n What types of side effects can I expect from the medication? The different gene that makes the Factor V Leiden protein is inherited from one or both parents. Food choices are varied enough that you can have a balanced diet and not get bored of foods. Medications to treat this condition may require dietary restrictions. If you have the prothrombin gene mutation but never had a deep vein thrombosis or pulmonary embolism before, you will not need a blood thinner during or after pregnancy. Bauer KA. Most people who have this disorder never develop blood clots or have pregnancy complications. People with Factor V Leiden make an altered factor V protein as a result of a mutated gene. between patient and physician/doctor and the medical advice they may provide. Anticoagulants are commonly used in the treatment of diseases in which there is an increased risk of blood clot formation. When taken with anticoagulants, binge-drinking alcohol can increase INR values. Accessed June 4, 2018. Alcohol interacts with a large number of medications. The clotting action of Factor V is controlled by another protein called Activated Protein C. To stop blood from forming clots, Activated Protein C easily turns off Factor V. Activated Protein C does not work as well on the abnormal Factor V Leiden protein. But if you have a blood clotting disorder, your blood forms clots more easily than normal. Middeldorp S, Coppens M. Hereditary Thrombophilia. You should either contact your provider or go to the nearest Emergency Room if you think youre having a deep vein thrombosis. The condition it self does not require a special diet. Genetic and Rare Disease Information Center. They were hot, red, and huge. Direct oral anticoagulants (DOACs) are expected to replace VKAs because of their increased safety margin. She graduated from the University of Sussex with a BA in Media Practice, having specialized in screenwriting. This site complies with the HONcode standard for trustworthy health information: verify here. Cranberry products are not significant unless taken in high amounts, as for urinary infections. If youcannot reach your doctor, go to the nearest hospital emergency room. 78 0 obj<>stream This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. Accessed June 4, 2018. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. you have a medical emergency, call 911 immediately. The disorder is most common in people who are white and of European descent. This content does not have an English version. The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. Current management strategies involve the use of pharmacotherapy, when indicated, in the event of deep venous thrombosis or pulmonary embolism. One or both of the factor V genes can be mutated and cause the altered form of the factor V protein known as the Factor V Leiden protein to be made. Want to talk about Multiple Myeloma: Anyone else? 0000229756 00000 n But your provider can help you keep your blood from clotting too much. Signs and symptoms may include: Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism. Avoidance of alcohol-containing beverages during long flights. It depends on the specific details of the previous deep vein thrombosis or pulmonary embolism. During long car rides, stop every few hours and take a short walk. These conditions can be life-threatening and require immediate medical treatment. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. What about my children?. About 1 of every 250 Black people in America has the prothrombin gene mutation. In your body, you have 50% Factor V Leiden and 50% normal Factor V. This happens in about 5 out of 100 people of Caucasian decent. If you are overweight or obese, consider the benefits of losing weight. US Pharm. If you or a loved one have factor V Leiden, you might feel scared about what the future will bring. But you should talk to your provider about what you can expect in your individual situation. Camomile in large quantities, a herbal treatment that is used to treat anxiety, catarrh and gastric problems, has also been implicated in a case of severe bleeding in a 70-year-old woman. There is no specific treatment for the mutation itself. Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. A family history of factor V Leiden increases your risk of inheriting the disorder. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. When you are ready, talk with your health care provider for advice and help to lose weight. Factor V is a protein that is needed for blood to clot properly. Having additional genetic blood clotting disorders. It is not a disease. As a result, your blood may clot more easily than it should, leading to serious complications. Do I need to take medication to prevent additional blood clots? Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: 1. This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. You do need treatment with blood thinners if you have had a blood clot or develop one in the future. In most people, a protein called activated protein C regulates the activity of . With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. The sooner you receive care, the better your chances of a good outcome. 0000001706 00000 n https://www.uptodate.com/contents/search. Factor V that becomes impaired can cause numerous issues with the health of the human blood. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. Youre might be wondering, Will this happen to me? The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Factor V is a protein that is needed for blood to clot properly. ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). The factor V Leiden mutation changes this proteins structure. This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. The Best Foods to Eat for Promoting Healthy Cells, Your 4-Week Mediterranean Diet Meal Plan, Curated by a Dietitian-Chef, Ready to Try the DASH Diet? Interactions which affect the efficacy of VKAs may result in bleeding from over-anticoagulation, or thrombosis due to under-anticoagulation. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either However, most people with this genetic mutation never develop these complications. Lockwood CJ, et al. Accessed June 4, 2018. That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. There are many programs, websites and tools that can help you quit. Avoid smoking, vaping and tobacco use. 5. You will most likely not have a dangerous blood clot, but your provider can provide counseling on how to reduce the risk of a deep vein thrombosis or pulmonary embolism. Youre at risk for having factor V Leiden if one of your parents carries a copy of the mutated F5 gene. Vitamin K is a necessary element in the blood clotting process. The nutrient can interact with blood-thinning meds, but the idea is not to avoid foods high in vitamin K, like broccoli, kale, spinach and collard greens. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. Are young and healthy when you get a clot. Some clots do no damage and disappear on their own. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. If you get the mutation from both of your parents, you are homozygous (you have two abnormal copies of the Factor II gene). of signs you need emergency medical attention or call 911. Factor V Leiden is a blood clotting disorder. National Heart, Lung, and Blood Institute. Venous thromboembolism. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. There is no specific "diet" for people with factor V Leiden, but there are foods that can help keep your blood and body healthy, which may reduce your risk of developing a blood clot. It is not associated with an increase risk of cancer or birth defects. Advertising revenue supports our not-for-profit mission. Vitamin K is necessary for making the proteins that aid in blood clotting, according to the Harvard T.H. You won't go hungry on The 5-Factor Diet. Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. Both men and women can have factor V Leiden. Zoppi, Lois. Tenderness or pain in your leg or arm, which you may only feel when standing or moving around. Anticoagulant Food-Drug Interactions. . Low Vitamin K consumption if on Coumadin/Warfarin. This means that for children with factor V Leiden, one out of 5,000-10,000 will get a blood clot. I WAS DIAGNOSED IN MARCH OF THIS YEAR AFTER HAVING MY 2ND PULMONARY EMBOLISM. The normal blood clotting process goes to work right away when you get a cut platelets rush to the site to seal it, and a substance called fibrin aided by factor V helps the platelets to form a clot. You must do the 25-minute 5-Factor workout five days a week. 9th ed. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. If you have an inactive (sedentary) lifestyle, consider how you could gradually increase your physical activity at home, school, work or play. 0000237253 00000 n There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. Can the results of the test affect my ability to obtain health insurance? Symptoms may resolve within days or months, depending on the location and severity of your deep vein thrombosis or pulmonary embolism. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. 0000002423 00000 n In: Williams Hematology. You may inherit an abnormal Factor II gene from one or both parents. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. This makes blood clots more likely to form, a condition called thrombophilia. Factor V Leiden thrombophilia. Vitamin K is found in the following foods: Liver meat Broccoli Brussels sprouts Cabbage Cheese Collard greens Kale Lentils Flaxseed Lettuce Spinach Soybean oil Turnip greens Camomile Green tea. 3. It may ease your mind to know that most people with this disorder never have a blood clot. If your provider feels its warranted, theyll order blood tests, including: Simply having a family history of blood clots may not be reason enough to run these tests. I was diagnosed in 2001 after a series of TIA's and a smart neurologist who suspected there was something more to be investigated since I had a history of DVT's and my mother's family has had numerous blood clots. (https://www.stoptheclot.org/learn_more/prothrombin-g20210a-factor-ii-mutation-links/), (https://www.merckmanuals.com/home/blood-disorders/excessive-clotting/excessive-clotting?query=prothrombin%20gene%20mutation). More info. Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. Learn more about symptoms, risk factors, causes, diagnosis, treatment, complications, and outlook . This helps keep the blood flowing in your legs. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. Signs of DVT: swelling or redness of your leg, with pain in your calf or inner thigh, Signs of PE: chest discomfort or shortness of breath. 0000001362 00000 n This gene is responsible for aiding in normal blood clotting. https://www.uptodate.com/contents/search. Larger than normal veins near your skins surface. xb```eB cg`a!OF'96L``XkeWp)8MenQLe*.,j(bicIgBvMS &"T$T'da[[N(~vS$ECp^e ^Ve'/ It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. Mayo Clinic does not endorse companies or products. In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed.
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